The Proposal

The National Institute for Research and Innovation in Photothermal Imaging (INPIIF) aims to organize a cooperative research and innovation network for the development of advanced methods of Optoacoustic, Photoacoustic and Photothermal imaging in the mid-infrared (MIR), with potential impact on preclinical research, clinical practice and materials science.

The Institute seeks to provide unprecedented information, currently unattainable with existing imaging modalities, involving simultaneous analysis of physicochemical and imaging properties through cutting-edge technologies and new techniques to be developed by INPIIF. There will be the innovative development of simultaneous measurement of images with gaseous biomarkers through photoacoustic detection.

The proposal brings together renowned Brazilian and international groups, several of which have established partnerships. The proposed imaging methods with detection by ultrasound sensors, microphones and optics are unique tools for the unprecedented advancement of simultaneous acquisition of images and absorption spectra in MIR.

Photoacoustic Spectroscopic Imaging.

The approach foresees the combination of these technologies with histopathology, FTIR, Raman Spectroscopy, LIBS, among others, focusing on the differentiation between healthy and compromised tissues, emphasizing support for the differential diagnosis of malignant tumors, pathogen-induced diseases, and monitoring of tissue repair processes and therapies such as photodynamics in in vitro, ex vivo and in vivo assays.

Optoacoustic Tomography in the Mid-Infrared spectral region.

The project includes the use of machine learning and the development of theoretical models to calculate the temperature increase induced by lasers in biological tissues, which are essential for clinical safety and precision.

Microscopy Imaging via Thermal Lens and Thermal Mirror methods.

INPIIF prioritizes the training of qualified human resources, interaction between students and researchers from network institutions, the dissemination of science, the transfer of knowledge to society and the productive sector, and internationalization.